SrasV1, France, Analysis, bibRecord, 000402

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

Identifieur interne : 000402 ( France/Analysis ); précédent : 000401; suivant : 000403

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

Auteurs : Christian Drosten [Allemagne] ; Stephan Günther [Allemagne] ; Wolfgang Preiser [Allemagne] ; Sylvie Van Der Werf ; Hans-Reinhard Brodt [Allemagne] ; Stephan Becker [Allemagne] ; Holger Rabenau [Allemagne] ; Marcus Panning [Allemagne] ; Larissa Kolesnikova [Allemagne] ; Ron A. M. Fouchier [Pays-Bas] ; Annemarie Berger [Allemagne] ; Ana-Maria Burguiere [France] ; Jindrich Cinatl [Allemagne] ; Markus Eickmann [Allemagne] ; Nicolas Escriou [France] ; Klaus Grywna [Allemagne] ; Stefanie Kramme [Allemagne] ; Jean-Claude Manuguerra [France] ; Stefanie Müller [Allemagne] ; Volker Rickerts [Allemagne] ; Martin Stürmer [Allemagne] ; Simon Vieth [Allemagne] ; Hans-Dieter Klenk [Allemagne] ; Albert D. M. E. Osterhaus [Pays-Bas] ; Herbert Schmitz [Allemagne] ; Hans Wilhelm Doerr [Allemagne]

Source :

The New England journal of medicine [ 0028-4793 ] ; 2003.

RBID : Pascal:03-0295886

Descripteurs français

KwdFr :
- ADN viral (analyse), ARN viral (analyse), ARN viral (sang), Adulte, Animaux, Bovins, Coronavirus (génétique), Données de séquences moléculaires, Expectoration (virologie), Femelle, Flambées de maladies, Humains, Mâle, Phylogénie, Réaction de polymérisation en chaîne, Similitude de séquences d'acides nucléiques, Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Séquence d'acides aminés, Séquence nucléotidique, Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (isolement et purification).
MESH :
- analyse : ADN viral, ARN viral.
- génétique : Coronavirus, Virus du SRAS.
- isolement et purification : Virus du SRAS.
- sang : ARN viral.
- virologie : Expectoration, Syndrome respiratoire aigu sévère.
- épidémiologie : Syndrome respiratoire aigu sévère.
Pascal (Inist)
- Adulte, Animaux, Bovins, Données de séquences moléculaires, Femelle, Flambées de maladies, Humains, Mâle, Phylogénie, Poumon pathologie, Détresse respiratoire adulte syndrome, Réaction de polymérisation en chaîne, Similitude de séquences d'acides nucléiques, Séquence d'acides aminés, Séquence nucléotidique, Virose, Homme, Coronavirus, Exploration microbiologique, Identification, Pathogénie, Prélèvement, Expectoration, Plasma sanguin, Fèces, Asie, SRAS, Syndrome respiratoire aigu sévère, Virus du SRAS.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Adult respiratory distress syndrome, Amino Acid Sequence, Animals, Asia, Base Sequence, Blood plasma, Cattle, Coronavirus, Coronavirus (genetics), DNA, Viral (analysis), Disease Outbreaks, Feces, Female, Human, Humans, Identification, Lung disease, Male, Microbiological investigation, Molecular Sequence Data, Pathogenesis, Phylogeny, Polymerase Chain Reaction, RNA, Viral (analysis), RNA, Viral (blood), SARS Virus (classification), SARS Virus (genetics), SARS Virus (isolation & purification), Samplings, Sequence Homology, Nucleic Acid, Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Sputum, Sputum (virology), Viral disease.
MESH :
- chemical , analysis : DNA, Viral, RNA, Viral.
- chemical , blood : RNA, Viral.
- classification : SARS Virus.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : Coronavirus, SARS Virus.
- isolation & purification : SARS Virus.
- virology : Severe Acute Respiratory Syndrome, Sputum.
- Adult, Amino Acid Sequence, Animals, Base Sequence, Cattle, Disease Outbreaks, Female, Humans, Male, Molecular Sequence Data, Phylogeny, Polymerase Chain Reaction, Sequence Homology, Nucleic Acid.

Abstract

BACKGROUND The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent. METHODS Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques. RESULTS A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent ofthe nucleotide sequence). On the basis ofthe obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated. CONCLUSIONS The novel coronavirus might have a role in causing SARS.

Url:

https://hal-pasteur.archives-ouvertes.fr/pasteur-00167033

Affiliations:

Links to Exploration step

Pascal:03-0295886

Le document en format XML

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<author><name sortKey="Muller, Stefanie" sort="Muller, Stefanie" uniqKey="Muller S" first="Stefanie" last="Müller">Stefanie Müller</name>
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<author><name sortKey="Rickerts, Volker" sort="Rickerts, Volker" uniqKey="Rickerts V" first="Volker" last="Rickerts">Volker Rickerts</name>
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<author><name sortKey="Sturmer, Martin" sort="Sturmer, Martin" uniqKey="Sturmer M" first="Martin" last="Stürmer">Martin Stürmer</name>
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<author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name>
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<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
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<country>Allemagne</country>
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</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Identification of a novel coronavirus in patients with severe acute respiratory syndrome</title>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
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</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gunther, Stephan" sort="Gunther, Stephan" uniqKey="Gunther S" first="Stephan" last="Günther">Stephan Günther</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
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<sZ>2 aut.</sZ>
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</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
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</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
</author>
<author><name sortKey="Brodt, Hans Reinhard" sort="Brodt, Hans Reinhard" uniqKey="Brodt H" first="Hans-Reinhard" last="Brodt">Hans-Reinhard Brodt</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Medical Clinic III, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Virology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rabenau, Holger" sort="Rabenau, Holger" uniqKey="Rabenau H" first="Holger" last="Rabenau">Holger Rabenau</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Panning, Marcus" sort="Panning, Marcus" uniqKey="Panning M" first="Marcus" last="Panning">Marcus Panning</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kolesnikova, Larissa" sort="Kolesnikova, Larissa" uniqKey="Kolesnikova L" first="Larissa" last="Kolesnikova">Larissa Kolesnikova</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Virology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Institute of Virology, Erasmus University</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berger, Annemarie" sort="Berger, Annemarie" uniqKey="Berger A" first="Annemarie" last="Berger">Annemarie Berger</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Burguiere, Ana Maria" sort="Burguiere, Ana Maria" uniqKey="Burguiere A" first="Ana-Maria" last="Burguiere">Ana-Maria Burguiere</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Pasteur Institute, Molecular Genetics of Respiratory Tract Viruses, National Influenza Center</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Virology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Pasteur Institute, Molecular Genetics of Respiratory Tract Viruses, National Influenza Center</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grywna, Klaus" sort="Grywna, Klaus" uniqKey="Grywna K" first="Klaus" last="Grywna">Klaus Grywna</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kramme, Stefanie" sort="Kramme, Stefanie" uniqKey="Kramme S" first="Stefanie" last="Kramme">Stefanie Kramme</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Pasteur Institute, Molecular Genetics of Respiratory Tract Viruses, National Influenza Center</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Muller, Stefanie" sort="Muller, Stefanie" uniqKey="Muller S" first="Stefanie" last="Müller">Stefanie Müller</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
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<sZ>17 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rickerts, Volker" sort="Rickerts, Volker" uniqKey="Rickerts V" first="Volker" last="Rickerts">Volker Rickerts</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Medical Clinic III, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sturmer, Martin" sort="Sturmer, Martin" uniqKey="Sturmer M" first="Martin" last="Stürmer">Martin Stürmer</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vieth, Simon" sort="Vieth, Simon" uniqKey="Vieth S" first="Simon" last="Vieth">Simon Vieth</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Virology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Institute of Virology, Erasmus University</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmitz, Herbert" sort="Schmitz, Herbert" uniqKey="Schmitz H" first="Herbert" last="Schmitz">Herbert Schmitz</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
<imprint><date when="2003">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Adult respiratory distress syndrome</term>
<term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Asia</term>
<term>Base Sequence</term>
<term>Blood plasma</term>
<term>Cattle</term>
<term>Coronavirus</term>
<term>Coronavirus (genetics)</term>
<term>DNA, Viral (analysis)</term>
<term>Disease Outbreaks</term>
<term>Feces</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Identification</term>
<term>Lung disease</term>
<term>Male</term>
<term>Microbiological investigation</term>
<term>Molecular Sequence Data</term>
<term>Pathogenesis</term>
<term>Phylogeny</term>
<term>Polymerase Chain Reaction</term>
<term>RNA, Viral (analysis)</term>
<term>RNA, Viral (blood)</term>
<term>SARS Virus (classification)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (isolation & purification)</term>
<term>Samplings</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Severe Acute Respiratory Syndrome (epidemiology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Severe acute respiratory syndrome</term>
<term>Sputum</term>
<term>Sputum (virology)</term>
<term>Viral disease</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (analyse)</term>
<term>ARN viral (analyse)</term>
<term>ARN viral (sang)</term>
<term>Adulte</term>
<term>Animaux</term>
<term>Bovins</term>
<term>Coronavirus (génétique)</term>
<term>Données de séquences moléculaires</term>
<term>Expectoration (virologie)</term>
<term>Femelle</term>
<term>Flambées de maladies</term>
<term>Humains</term>
<term>Mâle</term>
<term>Phylogénie</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Syndrome respiratoire aigu sévère (épidémiologie)</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Viral</term>
<term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ADN viral</term>
<term>ARN viral</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Expectoration</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
<term>Sputum</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Cattle</term>
<term>Disease Outbreaks</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Polymerase Chain Reaction</term>
<term>Sequence Homology, Nucleic Acid</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Animaux</term>
<term>Bovins</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Flambées de maladies</term>
<term>Humains</term>
<term>Mâle</term>
<term>Phylogénie</term>
<term>Poumon pathologie</term>
<term>Détresse respiratoire adulte syndrome</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Virose</term>
<term>Homme</term>
<term>Coronavirus</term>
<term>Exploration microbiologique</term>
<term>Identification</term>
<term>Pathogénie</term>
<term>Prélèvement</term>
<term>Expectoration</term>
<term>Plasma sanguin</term>
<term>Fèces</term>
<term>Asie</term>
<term>SRAS</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">BACKGROUND The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent. METHODS Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques. RESULTS A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent ofthe nucleotide sequence). On the basis ofthe obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated. CONCLUSIONS The novel coronavirus might have a role in causing SARS.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
<li>Pays-Bas</li>
</country>
<region><li>District de Darmstadt</li>
<li>District de Giessen</li>
<li>Hambourg</li>
<li>Hesse (Land)</li>
<li>Hollande-Méridionale</li>
<li>Île-de-France</li>
</region>
<settlement><li>Francfort-sur-le-Main</li>
<li>Hambourg</li>
<li>Marbourg</li>
<li>Paris</li>
<li>Rotterdam</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
</noCountry>
<country name="Allemagne"><region name="Hambourg"><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
</region>
<name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
<name sortKey="Berger, Annemarie" sort="Berger, Annemarie" uniqKey="Berger A" first="Annemarie" last="Berger">Annemarie Berger</name>
<name sortKey="Brodt, Hans Reinhard" sort="Brodt, Hans Reinhard" uniqKey="Brodt H" first="Hans-Reinhard" last="Brodt">Hans-Reinhard Brodt</name>
<name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name>
<name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name>
<name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name>
<name sortKey="Grywna, Klaus" sort="Grywna, Klaus" uniqKey="Grywna K" first="Klaus" last="Grywna">Klaus Grywna</name>
<name sortKey="Gunther, Stephan" sort="Gunther, Stephan" uniqKey="Gunther S" first="Stephan" last="Günther">Stephan Günther</name>
<name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
<name sortKey="Kolesnikova, Larissa" sort="Kolesnikova, Larissa" uniqKey="Kolesnikova L" first="Larissa" last="Kolesnikova">Larissa Kolesnikova</name>
<name sortKey="Kramme, Stefanie" sort="Kramme, Stefanie" uniqKey="Kramme S" first="Stefanie" last="Kramme">Stefanie Kramme</name>
<name sortKey="Muller, Stefanie" sort="Muller, Stefanie" uniqKey="Muller S" first="Stefanie" last="Müller">Stefanie Müller</name>
<name sortKey="Panning, Marcus" sort="Panning, Marcus" uniqKey="Panning M" first="Marcus" last="Panning">Marcus Panning</name>
<name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name>
<name sortKey="Rabenau, Holger" sort="Rabenau, Holger" uniqKey="Rabenau H" first="Holger" last="Rabenau">Holger Rabenau</name>
<name sortKey="Rickerts, Volker" sort="Rickerts, Volker" uniqKey="Rickerts V" first="Volker" last="Rickerts">Volker Rickerts</name>
<name sortKey="Schmitz, Herbert" sort="Schmitz, Herbert" uniqKey="Schmitz H" first="Herbert" last="Schmitz">Herbert Schmitz</name>
<name sortKey="Sturmer, Martin" sort="Sturmer, Martin" uniqKey="Sturmer M" first="Martin" last="Stürmer">Martin Stürmer</name>
<name sortKey="Vieth, Simon" sort="Vieth, Simon" uniqKey="Vieth S" first="Simon" last="Vieth">Simon Vieth</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name>
</region>
<name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Burguiere, Ana Maria" sort="Burguiere, Ana Maria" uniqKey="Burguiere A" first="Ana-Maria" last="Burguiere">Ana-Maria Burguiere</name>
</region>
<name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name>
<name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Identification of a novel coronavirus in patients with severe acute respiratory syndrome
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Identification of a novel coronavirus in patients with severe acute respiratory syndrome

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

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